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Acne drug linked to bowel disease

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Acne drug linked to bowel disease

Individuals receiving the acne drug isotretinoin are four times more likely to develop a bowel disease known as ulcerative colitis within a year of consumption.

Isotretinoin, best known by the brand-name Accutane, is commonly used for the treatment of severe recalcitrant acne. Serious side effects such as suicidal tendencies and liver damage are reported following the use of the drug.

Certain associations of the drug and inflammatory bowel disease (IBD) — a group of inflammatory disorders of the gastrointestinal tract, including ulcerative colitis and Crohn’s disease — had already been reported; the definite association, however, has yet to be confirmed.

According to a study published in the American Journal of Gastroenterology, isotretinoin may affect the immune function in the intestines, increasing the risk of IBD. The relative risk of the condition is probably quite small.

While isotretinoin users are at a four times higher risk of developing ulcerative colitis, such an association is not reported for Crohn’s disease. Severe acne was also not linked to an increased risk of IBD.

The risk of ulcerative colitis increases in tandem with the patient’s daily dose of the drug, pointing out a cause-and-effect relationship between the conditions.

Sun, 11 Apr 2010 12:23:10 GMT

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Written by CarlAn

11/04/2010 às 16:41

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